Synthetic pathways have been constructed in bacteria to create valuable chemicals and products. These pathways have to be optimized and balanced to achieve appropriate levels of enzymes that catalyze each step. The expression of each enzyme needs to be carefully controlled, and one area that is relatively unexplored and underutilized as a method of gene expression control is RNA stability. I will share my research investigating a ribonuclease that cleaves double-stranded RNA and discuss global RNA turnover in cyanobacteria and our efforts to identify stabilizing and de-stabilizing elements.
All qBio sponsored talks take place on Wednesdays at 2:00 p.m. in the 3rd floor Orchard View room of the Discovery Building unless otherwise noted. Talks are open to the public. Access to the room is via the elevator behind Aldo’s Cafe in the Northeast corner of the building.